DOXORUBICIN-INDUCED PLATELET ACTIVATION AND CLEARANCE RELIEVED BY SALVIANOLIC ACID COMPOUND: NOVEL MECHANISM AND POTENTIAL THERAPY FOR CHEMOTHERAPY-ASSOCIATED THROMBOSIS AND THROMBOCYTOPENIA

Doxorubicin (Dox) is a widely utilized chemotherapeutic; however, it carries side effects, including drug-induced immune thrombocytopenia (DITP) and increased risk of venous thromboembolism (VTE).Currently, the mechanisms for Dox-associated DITP and VTE are poorly understood, and an effective inhibitor to relieve these complications remains to be d

Research in the synthesis of Schiff base ligands and their metal complexes using olive leaf extracts as a green reducing agent is an exciting area of study.In this research, a Schiff base ligand is created by combining 1-hydroxy-2-naphthaldehyde and amino-N-(4,6-dimethylpyrimidin-2-yl)-4-benzenesulfonamide.The synthetic Schiff base is then utilized

Thirty-two novel hybrid transmissions consisting of a Ravigneaux gear train and a single planetary gear train are synthesized using a creative design methodology based on graph-theory and the lever analogy method.The design process Spatula commences by identifying an existing transmission configuration which meets all of the design requirements.The

Healthcare workers (HCWs) faced a range of stressors during the coronavirus (COVID-19) pandemic, contributing to psychological stress.We use a psychological trauma framework to characterize the mental health burden for clinical and non-clinical healthcare worker occupations during the COVID-19 pandemic.The objective was to measure and characterize